TURMERIC EXTRACT/ CURCUMIN POWDER(CPE – 024)
PRODUCT INFORMATION

Apart from being used for centuries in Indian traditional system as a spice and a natural food color, Turmeric is also widely known and used for its medicinal values. Tumeric has shown to have excellent anti-tumor effects. Turmeric possess anti-inflammatory, anti-allergic and antibacterial activity. It helps to prevent/retard various cardio-vascular, viral and other chronic diseases like arthritis cancer and AIDS, by neutralizing existing free radicals.

Introduction

Turmeric consists of dried as well as fresh rhizomes of the plant Curcuma longa(family Zingiberaceae). Rhizome is the portion of the plantthat isused for medical purposes. Turmeric, best known as “Harida” in Sanskrit has been used for centuries In Ayurveda, internally as a stomachic, tonic and blood purifier and topically in the prevention and treatment of skin diseases. It has been also applied to bruises, sprains, wounds, and inflammation. It is applied to skin to alleviate pain, inflammation and to promote healing in pemphigus, shingles etc. Mixed with borax, a paste, turmeric is applied to reduce tissue swelling. Several studies suggests curcumin as well as turmeric reduce the gastric secretion. It is an effective choleritic agent increasing bile acid output over 100%. It has immunostimulant actions, anticancer action. It showed invitro bacteriocidal action against a variety of micro organisms like Staphylococcus aureus, Micrococcus pyrogenes etc. Curcumin is used, as a spice and natural food colour and preservative. It was found to be comparatively effective as an anti-arthritic agent as phenyl bentazone. In case of arthritis, best results are observed when given in combination with Boswellia serrata extract.

Extraction .

Curcumin extract (CPE-024) is obtained by crystallizing turmeric oleoresin, which is prepared by the solvent extraction of turmeric. Curcumin, the active ingredient present in turmeric is responsible for the biological activities of turmeric. The product which is in the powder form contains about 92-96% curcuminoids. RHULIEF TM is a herbal preparation developed by the R&D wing of A.N.E.L. It contains a unique blend of Boswellic acids (Boswellia serrata) and curcuminoids (Curcuma longa) mainly indicated as an anti-inflammatory and anti-arthritic agent in osteo and rheumatoid arthritis.

Physiological significance

Turmeric extract demonstrated decreased susceptibility of LDL to lipid peroxidation, in addition to lower plasma cholesterol & triglyceride level, shows a protective effects on Central Vascular System. Turmeric has been shown to inhibits ulcer formation caused by stress, alcohol, indomethacin, pyloric ligation & reserpine in animal studies. This study demonstrated turmeric extract significantly increased the gastric wall mucus in rats subjected to these gastro intestinal insults. Curcuma longa significantly reduced inflammatory swelling. Animal studies involving rats & mice as well as in vitro studies utilizing human cell lines have demonstrated curcumin’s ability to inhibit carcinogenesis at three stages: Tumor promotion, angiogenesis & tumour growth. In cases of sub acute liver injury, curcumin administration significantly decreased certain liver enzyme values, resulting in decreased liver injury in test animals compared to controls B

Uses

Curcumin exhibits remarkable anti-inflammatory activity. It is also known to possess antihepatotoxic, antiulcer and antibacterial properties. Cytotoxic effects of curcuminoids is increasingly known to play an important role in the treatment of certain cancerous conditions.

Mechanism of action:

Curcumin shows enhanced cellular resistance to oxidative damage. Curcumin’s action resulted in a decrease in mRNA levels & nitric oxide synthase activity. Sodiumcurcuminate, a salt of curcumin, also exerts choleretic effects by increasing bilary excretion of bile salts, cholesterol and bilirubin, as well as increasing bile solubility, therefore possibly preventing & treating cholelithiasis. Curcumin’s antiinflammatory property may be the ability to inhibit proinflammatory arachidonic acid, as well as neutrophil function during inflammatory states. It enhances body’s natural antioxidant system, increasing glutathione levels, thereby aiding in hepatic detoxification of mutagens & carcinogens & inhibiting nitrosamine formation

Toxicity

No significant toxicity has been reported following either acute or chronic administration of turmeric extracts at standard doses. It was found to be non toxic even up to 1800mg/kg body weight.

Contra Indications & warning:

At very high doses (2000mg/kg body weight), Curcumin was found ulcergenic in animals.

Dosage:

Recommended dosage is 500-3000mg per day. Higher doses are recommended during pathological conditions
References:
  • Anti-hepato toxic principles of curcuma longa rhizomes. Planta Med. 1983;49;185.
  • Anti-inflammatory studies on Turmeric. Ind J med Res 1971;59;1289.
  • Inhibition of chemical Carcinogenesis by Curcumin. J.Ethnopharmacol .1989;27;227.
  • Absorption and tissue distribution of curcumin in rats. Toxicol 1980 16,259.
  • A simple and efficient separation of Curcumins, the antiprotozoal constituents of curcuma longa. Planta Med. 2000;66;396
  • Textbook of Natural Medicine,2 nd Edn, London :ChurchillLivingstone.;1999;689.
  • Curcumin, (1987) Drugs of the future Vol:12, No:4
  • Indian Materia Medica (1976). Vol:1 pp:418
  • Indian Herbal Pharmacopoeia (2002) pp:169-178
TURMERIC EXTRACT / CURCUMIN POWDER
Specification ( General )
Product name Turmeric extract / Curcumin powder
Product code CPE – 024
Odour and taste Characteristic – turmeric like
Colour and appearance Yellowish to orange red free flowing powder
Active ingredients

Curcumin

Curcumin content

92 – 96% (UV method)

Bulk density (Gm/Ml) (Tapped) 0.55– 0.85
Bulk density (Gm/Ml) (Untapped) 0.35– 0.65
Volatile oil content Below 2%
Residual solvent

Ethyl acetate - below 30 ppm

Solubility Completely soluble in acetone
Heavy metal
Total heavy metals Less than 10 ppm
Lead Less than 5 ppm

Microbiological assays
Total plate count (CFU/GM) 1000 maximum
Yeast and Mould (CFU/GM 100 maximum
Salmonella

Negative

Packing 25 kgs HDPE drums with outer carton packing
Storage

Keep in cool and inert atmosphere, away from moisture. Stable under inert conditions

Shelf life 24 months
Physical and chemical properties
Molecular formula I - C 21H 20O 6
II - C 20H 13O 5
III - C 19H 16O 4
Molecular weight I - 368.39
II - 338.39
III - 308.39

Chemical name

 

I:

1, 7 - Bis ( 4 - hydroxy - 3 - methoxy phenyl ) hepta - 1,6 - diene - 3, 5 dione
II: 1 - ( 4 - hydroxy phenyl ) - 7 - ( 4 - hydroxy - 3 - methoxy - phenyl - ) hepta - 1,6 - diene 3, 5 - dione
III: 1,7 - Bis ( 4 - hydroxy phenyl ) hepta 1,6 diene 3,5 - dione
   

CERTIFICATE OF ANALYSIS
Product name

Turmeric extract / Curcumin powder

Product code CPE – 024
Batch No

CPE – 024/0611/RD-11

Colour and appearance

Orange red free flowing powder

Odour and taste Characteristic – turmeric like
Bulk density (Gm/Ml) (Tapped)

0.72

Bulk density (Gm/Ml) (Untapped)

0.57

Curcumin content 95.9% (UV method)
Volatile oil content(ml/100 gm)

1.2%

Residual solvent

Ethyl acetate – 14 ppm

Solubility Completely soluble in acetone
Heavy metals
Total heavy metals

Ethyl acetate – 14 ppm

Lead Completely soluble in acetone

Microbiological assays
Total plate count (CFU/GM

60

Yeast and Mould (CFU/GM)

Not detected

Salmonella Negative
E. Coli (CFU/GM) Negative
Manufacturing date

01/11/2006

Expiry date

31/10/2008

Shelf life 24 months

MATERIAL SAFETY DATA SHEET
Product name

Turmeric extract / Curcumin powder

1. Chemical product & company identification
Product name Turmeric extract / Curcumin powder
Product code

CPE - 024

Company name

Arjuna Natural Extracts Ltd.

Company address PB No. 126, Bank road,
Aluva - 683 101., Kerala , India .
Company tel. no

91-484-2622204/2622612

Company fax no

91-484-2532404/2622612

Company emergency tel. no 91-484-2623939
2. Composition/information on ingredients
Physical state

Product is a free flowing powder

Common name Turmeric extract
CAS - number

N.d.a

EC - number N.d.a
EINECS - numbe

207 - 280 - 5

INCI Curcuma longa
Colour and index number

75300

Synonyms Natural yellow, Turmeric yellow, curcumin dye, Diferoyl methane
Impurities

None

3. Hazards identification

Physical and chemical hazards

None

Environmental hazards

None

Adverse human health effects

None

Specific hazards None
Main symptoms

None

4. First - aid measures

Symptoms and effects
Inhalation

Irritation

Skin contact

Yellow pigmentation to the skin

Eye contact Slight irritation due to the curcumin present
Ingestion None

First aid

Inhalation Seek medical advice if discomfort feels
Skin contact Wipe off with alcohol ( ethyl alcohol ) hen with suitable detergent and water
Eye contact Rinse with plenty of water containing suitable detergent
Ingestion

Consult a doctor if discomfort feels

5. Fire fighting measures
Suitable extinguishing media

Water, CO 2, foam

Extinguishing media which must not be used

None

Exposure hazards On incineration emit fumes
Special protective equipment for fire fighters None
Special fire fighting methods None

6. Accidental release measures

Personal precautions

Use gloves

Environmental precautions

None

Methods for cleaning up Flush with plenty of water containing with suitable detergents
Methods for recovery

None

Methods of neutralization Not necessary
Methods for disposal

Landfill

7. Handling & storage  
Handling
Prevention of exposure

None

Prevention of fire/explosion None
Precaution for safe handling None
Safe handling advice Good house keeping practices

Storage

Suitable storage media All steel and HM-HDPE pails
Recommendations

Avoid high temperature and long storage time, keep container closed

Incompatible materials

N.d.a

8. Exposure controls/personal protection

Specific control parameters

Limit values

N.d.a

Biological standards

N.d.a

Means for personal protection

Respiratory protection None
Hand protection Wear gloves
Skin and body protection Wear suitable protective clothes
Hygiene measures Good house keeping practices
Engineering measures

N.d.a

9. Physical and chemical properties

Physical state

Free flowing powder

Colour

Yellowish to orange red

 

Odour

Spicy like turmeric

pH 6 - 8
Melting point

175 - 185 oC

Flash point

N.d.a

Explosive properties

None

Bulk density (Gm/Ml) (Tapped)

0.55– 0.85

Solubility in acetone

Complete soluble

Decomposition temperature Above 200 O C
10. Stability and reactivity
Conditions to avoid

High temperature and high humidity

Materials to avoid Iron, copper
Hazardous decomposition products

None

11. Toxicological informations

 
Acute toxicity Biochemically, haematologically and histopathologically non-toxic
Inhalation

N.d.a

Ingestion

N.d.a

Skin contact

N.d.a

Eye contact

Slight irritation due to the curcumin present

Chronic long term toxicity Turmeric extract / Curcumin powder is considered as non- toxic and non-carcinogenic
12. Ecological information
Mobility

Free flowing powder

Solubility

Soluble in acetone

Persistence/degradability Bio-degradable
Bio-accumulation None
Eco-toxicity Insignificant toxic hazard

13. Disposal considerations

Water/residue

Waste water treatment plant

Package Regular disposal after washing with water and detergent
14. Transport information
IMCO ( sea )

N.d.a

ICAO/IATA ( air

N.d.a

RID/ADR ( land )

N.d.a

UN - number

N.d.a

Packaging group

N.d.a

15. Regulatory information

Specific international regulation Compiles with several food and pharmaceutical regulations
Specific national regulation

N.d.a

Labeling

N.d.a

( N.d.a - No data available )

© 2005 Arjuna Natural Extracts Ltd